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Premier League clubs return to action this weekend as we head into the twilight of an enthralling 2025/26 campaign.
There’s still plenty to play for on both ends of the Premier League table, although Burnley and Wolverhampton Wanderers already have their fates set in stone.
Nevertheless, there are a number of eye-catching fixtures that are poised to shake up the Premier League table after matchday 28.
The Emirates Stadium forms the backdrop for this weekend’s headline fixture as Arsenal host London rivals Chelsea north of the capital on Sunday.
The Blues will relish the opportunity to throw a wrench in Arsenal’s title hopes, but they have failed to get the better of their North London counterparts in three attempts already this season.
In fact, that record will bolster the confidence in Arsenal’s dressing room ahead of kick-off, with Mikel Arteta’s side keen to consolidate their spot at the top of the table.
Fans will also be keeping an eye on Craven Cottage, where Fulham host Tottenham Hotspur in Igor Tudor’s second Premier League outing as Spurs interim manager.
It’ll be interesting to see how quickly he can get his message across, particularly after last weekend’s harsh reality check in the North London derby.
West Ham United will also be desperate to pick up points despite facing an uphill task against Liverpool at Anfield, while Nottingham Forest visit Brighton & Hove Albion as the battle for survival heats up.
Injuries, suspensions, and late fitness doubts will play a major role in deciding how teams line up and perform this weekend, so we’ve highlighted all the latest injury news for each club ahead of matchday 28.
Wolverhampton Wanderers vs Aston Villa (Friday, 9pm)
Wolverhampton Wanderers
Out: Leon Chiwome (knee), Hwang Hee-Chan (calf)
Aston Villa
Out: Boubacar Kamara (knee), John McGinn, Youri Tielemans (ankle), Alysson (knock), Harvey Elliott (knock)
Bournemouth vs Sunderland (Saturday, 3:30pm)
Bournemouth
Out: Ben Gannon-Doak (hamstring), Matai Akinmboni (muscle), Justin Kluivert (knee), Julio Soler (hamstring), Lewis Cook (hamstring)
Sunderland
Out: Nordi Mukiele, Bertrand Traore (knee), Djiamgone Jocelin Ta Bi (ankle), Reinildo (knee), Brian Brobbey (knock), Romaine Mundle (knock), Dennis Cirkin (knock)
Burnley vs Brentford (Saturday, 4pm)
Burnley
Out: Connor Roberts (knock), Jordan Beyer (knee), Zeki Amdouni (knee), Josh Cullen (knee), Mike Tresor (knock), Axel Tuanzebe (Achilles), Armando Broja (knock)
Brentford
Out: Antoni Milambo (knee), Fabio Carvalho (knee), Josh Dasilva (knee)
Liverpool vs West Ham United (Saturday, 4pm)
Liverpool
Out: Florian Wirtz (back), Wataru Endo (foot), Jeremie Frimpong, Alexander Isak (ankle), Giovanni Leoni (knee), Stefan Bajcetic (hamstring), Conor Bradley (knee), Jayden Danns (hamstring)
West Ham United
Out: Pablo Felipe (calf), Lukasz Fabianski (back), Freddie Potts (hamstring)
Newcastle United vs Everton (Saturday, 4pm)
Newcastle
Out: Bruno Guimaraes (hamstring), Lewis Miley (knock), Emil Krafth (knee), Fabian Schar (ankle), Valentino Livramento (hamstring)
Everton
Out: Jack Grealish (foot), Mark Travers (finger), Charly Alcaraz
Leeds United vs Manchester City (Saturday, 6:30pm)
Leeds United
Out: Noah Okafor (hamstring)
Manchester City
Out: Max Alleyne (knock), Jeremy Doku (calf), Mateo Kovacic (ankle), Josko Gvardiol (shin)
Brighton & Hove Albion vs Nottingham Forest (Sunday, 3pm)
Brighton & Hove Albion
Out: Yasin Ayari (shoulder), Adam Webster (knee), Solly March (knee), Stefanos Tzimas (knee)
Nottingham Forest
Out: Chris Wood (knee), John Victor (knock), Matz Selz (groin), Nicolo Savona (knee), Willy Boly (knee)
Fulham vs Tottenham Hotspur (Sunday, 3pm)
Fulham
Out: Kevin, Sasa Lukic (hamstring), Samuel Chukwueze (calf), Antonee Robinson (ankle)
Tottenham Hotspur
Out: Wilson Odobert (ACL), Destiny Udogie (hamstring), Dejan Kulusevski (knee), James Maddison (knee), Mohammed Kudus (thigh), Rodrigo Bentancur (hamstring), Ben Davies (ankle), Lucas Bergvall (ankle)
Doubtful: Kevin Danso (foot), Pedro Porro (hamstring)
Manchester United vs Crystal Palace (Sunday, 3pm)
Manchester United
Out: Patrick Dorgu (muscle), Matthijs de Ligt (back), Mason Mount (knock), Lisandro Martinez (knock)
Crystal Palace
Out: Maxence Lacroix (adductor), Jean-Philippe Mateta (knee), Jefferson Lerma (hamstring), Eddie Nketiah (hamstring), Cheick Doucoure (knee)
Arsenal vs Chelsea (Sunday, 5:30pm)
Arsenal
Out: Kai Havertz, Mikel Merino (foot), Maz Dowman (ankle)
Chelsea
Out: Marc Cucurella (hamstring), Estevao Willian (hamstring), Jamie Gittens (hamstring), Levi Colwill (knee), Dario Essugo (thigh), Filip Jorgensen (knock).