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NFL Week 2 Odds Released

Published September 14, 2026 · Updated September 14, 2026 · Fox Sports

NFL Week 2 betting odds are now available, featuring the Lions vs. Bills Thursday night clash as the marquee matchup.

Thursday night's Lions vs. Bills game headlines NFL Week 2 action, with the Bills favored by 3.5 points (-185 moneyline) and the over/under set at 53.5. Complete betting lines for all 16 matchups are now available through legal sportsbooks, with favorites including the Buccaneers (-8.5 vs. Browns), Ravens (-8.5 vs. Saints), and 49ers (-12.5 vs. Dolphins). cricket-ipl.in

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