Argentina stars Lautaro and Soulé are expected to start for Inter, aiming to lift the Nerazzurri after a three-match winless run. Roma, chasing Champions League spots, face a difficult trip to the leaders.
Inter will be without Yann Bisseck and suspended Carlos Augusto. Roma travel without Evan Ferguson, Manu Koné, Paulo Dybala, Artem Dovbyk, and Wesley. Kickoff is at 20:45 CET.